TL neuro

July 6, 2011

Wheel activity and MDMA hyperthermia

Filed under: MDMA, Methamphetamine, Thermoregulation — mtaffe @ 2:18 pm

The following has been assigned an issue in Pharmacology, Biochemistry & Behavior

Gilpin NW, Wright MJ Jr, Dickinson G, Vandewater SA, Price JU, Taffe MA. Influences of activity wheel access on the body temperature response to MDMA and methamphetamine., Pharmacol Biochem Behav. 2011 Sep;99(3):295-300. Epub 2011 May 13. DOI PubMed

In this paper we report that while the opportunity to run on an activity wheel does not increase the mean body temperature increase associated with 10 mg/kg MDMA in rats, the two correlate across individuals. Also, the individuals who ran most / increased their temperature most were at increased risk of 24-hr mortality, despite having stable body temperature 6 hrs post dosing.

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