TL neuro

August 15, 2011

Concurrent Methamphetamine IVSA and Wheel Activity Paper

Filed under: Exercise, Methamphetamine — mtaffe @ 9:45 am

The following has been accepted for publication:

Miller, M.L., Vaillancourt, B.D., Wright Jr., M.J., Aarde, S.M., Vandewater, S.A., Creehan, K.M. and Taffe, M.A. Reciprocal inhibitory effects of intravenous d-methamphetamine self-administration and wheel activity in rats, 2012, Drug Alcohol Depend, 121:90-96 [Sep 5, 2011 Epub ahead of print]

In this paper we show that when rats are provided concurrent access to an activity wheel during the initial acquisition of methamphetamine self-administration, they take less drug.

In addition, a prior history of 7 or 14 self-administration sessions reduces the amount rats will subsequently run on the wheel when provided with concurrent access.

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Additional reading:
Smith et al 2011b, 2011a, 2008b, 2008a

Lynch et al, 2010

Cosgrove et al 2002

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