TL neuro

July 9, 2012

Mephedrone decreases body temperature, fails to generate hyperthermia at high ambient temperature

Filed under: 4-MMC/Mephedrone, Cathinones, MDMA, Methamphetamine — mtaffe @ 11:29 am

The following has been accepted for publication:

Miller, M.L., Creehan, K.M., Angrish, D., Barlow, D.J., Houseknecht, K.L., Dickerson, T.J. and Taffe, M.A. Changes in ambient temperature differentially alter the thermoregulatory, cardiac and locomotor stimulant effects of 4-methylmethcathinone (mephedrone), Drug Alcohol Depend, 2013 Jan 1;127(1-3):248-53. doi: 10.1016/j.drugalcdep.2012.07.003. Epub 2012 Jul 23.[PubMed]

In this study, rats were monitored for changes in body temperature, home cage ambulatory activity and heart rate after the administration of 4-methylmethcathinone (4-MMC or mephedrone). The study was conducted at low (20°C) and high (30°C) ambient temperature because prior work has shown that 3,4-methylenedioxymethamphetamine (MDMA) produces hypothermia at low ambient and hyperthermia at high ambient temperature in rats (Malberg and Seiden, 1998; Dafters et al, 1994). As discussed in a prior post on the neuropharmacology of 4-MMC, and our recent study (Huang et al, 2012) on the effects of 4-MMC, MDMA and methamphetamine on wheel activity [ blogpost ], there is reason to believe the effects of this cathinone would be similar to those of MDMA.

The main finding was that 4-MMC (1.0-5.6 mg/kg, s.c.) caused a dose-dependent decrease in body temperature under 20°C ambient conditions but no alteration at the higher ambient temperature. A followup experiment showed that 5.6 mg/kg MDMA, s.c., increased body temperature, similar to findings in prior studies. Therefore, it appears that the risk for hyperthermia is attenuated for 4-MMC compared with MDMA. Locomotor activity in the home cage was dose-dependently increased by 4-MMC with greater stimulation at the higher ambient temperature condition. The maximum locomotor increase under 30°C ambient conditions was less than that produced by 5.6 mg/kg MDMA and similar to that produced by 1.0 mg/kg methamphetamine. Effects of 4-MMC on heart rate were modest with a reduction relative to vehicle observed in the low ambient temperature condition only.


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