TL neuro

February 6, 2014

DEA places 10 more cathinone stimulants (“bath salts”) under Schedule I control

Filed under: Cathinones — mtaffe @ 4:57 pm

A notice in the Federal Register on Jan 28, 2014 notifies us of the action.

SUMMARY: The Deputy Administrator of the Drug Enforcement Administration (DEA) is issuing this notice of intent to temporarily schedule 10 synthetic cathinones into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act (CSA). The 10 substances are: (1) 4-methyl-N-ethylcathinone (“4-MEC”); (2) 4-methyl-alpha-pyrrolidinopropiophenone (“4-MePPP”); (3) alpha-pyrrolidinopentiophenone (“[alpha]-PVP”); (4) 1-(1,3-benzodioxol-5-yl)-2-(methylamino)butan-1-one (“butylone”); (5) 2-(methylamino)-1-phenylpentan-1-one (“pentedrone”); (6) 1-(1,3-benzodioxol-5-yl)-2-(methylamino)pentan-1-one (“pentylone”); (7) 4-fluoro-N-methylcathinone (“4-FMC”); (8) 3-fluoro-N-methylcathinone (“3-FMC”); (9) 1-(naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one (“naphyrone”); and (10) alpha-pyrrolidinobutiophenone (“[alpha]-PBP”). This action is based on a finding by the Deputy Administrator that the placement of these synthetic cathinones into schedule I of the CSA is necessary to avoid an imminent hazard to the public safety. Any final order will be published in the Federal Register and may not be effective prior to February 27, 2014. Any final order will impose the administrative, civil, and criminal sanctions and regulatory controls applicable to schedule I substances under the CSA on the manufacture, distribution, possession, importation, exportation, research, and conduct of instructional activities of these synthetic cathinones.

I’ve relisted them just to summarize with the most recognizable names:
4-MEC (4-methyl-N-ethylcathinone)
alpha-PVP (alpha-pyrrolidinopentiophenone)
alpha-PBP (alpha-pyrrolidinobutiophenone)
4-MePPP (4-methyl-alpha-pyrrolidinopropiophenone)
Butylone (bk-MBDB)
Pentylone (bk-MBDP)
Flephedrone (4-fluoro-N-methylcathinone, 4-FMC)
3-fluoro-N-methylcathinone, 3-FMC

Some pharmacological studies on Butylone, Flephedrone and Naphyrone were presented in Simmler et al, 2013 (Br J Pharmacol. 2013 Jan;168(2):458-70. doi: 10.1111/j.1476-5381.2012.02145.x.). Likewise, some pharmacological details on 4-MEC, Pentylone, Pentedrone and 3-FMC are in Simmler et al. 2013preprint (Neuropharmacology. 2013 Nov 22;79C:152-160. doi: 10.1016/j.neuropharm.2013.11.008.)

Data presented in December at the ACNP meeting suggest that alpha-PVP and alpha-PBP are relatively selective dopamine transporter blockers with minimal ability to release monoamines. This is consistent with their close structural relationship with MDPV.


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