TL neuro

June 3, 2016

Inhalation delivery of psychostimulants to rats using e-vape technology » Vape-IP-ICSS

Vape decreases ICSS thresholds

Inhaled and intraperitoneal exposure to mephedrone (4MMC; 200 mg/mL in PG), methamphetamine (MA; 100 mg/mL) and 3,4-methylenedioxypyrovalerone (MDPV; 100 mg/mL) decreases threshold of intracranial self-stimulation reward. A) Mean (N=9-10; ±SEM) change in ICSS threshold produced by i.p. administration of saline, 4MMC (1.0mg/kg), MA (0.5 mg/kg) or MDPV (0.5 mg/kg) is compared with the average of the two exposures to inhaled PG, 4MMC, MA or MDPV. B) Mean (N=10; ±SEM) change in ICSS threshold produced by i.p. administration of three doses of 4MMC, MA and MDPV. In all panels, significant differences from the respective Vehicle condition is indicated by *.

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