TL neuro

April 13, 2017


Filed under: Careerism, NIH — mtaffe @ 10:11 am

In 2017 the NIH issued NOT-OD-17-050 Reporting Preprints and Other Interim Research Products to encourage funded investigators to speed the dissemination of tax-payer funded research by citing and claiming pre-prints as products of NIH funding.

The NIH encourages investigators to use interim research products, such as preprints, to speed the dissemination and enhance the rigor of their work. This notice clarifies reporting instructions to allow investigators to cite their interim research products and claim them as products of NIH funding.

Pre-prints are manuscripts (and other interim research products) which have not undergone peer-review and formal acceptance for publication.

The most critical implication of this new policy is for grant preparation.

Interim research products can be cited anywhere other research products are cited.  These sections include the following:

The benefits should be clear. Instead of having to describe work as being “in preparation” or “submitted” one can now point to a link and any interested reviewers can see it for themselves. This will be critical on the CV or Biosketch of junior scientists in transition. The publishing timeline is slow compared to their needs with respect to finding a postdoc appointment after graduate school, winning a fellowship as a postdoc or getting a job offer after postdoctoral training.

This will potentially help all PIs with their grant applications as well. Productivity can be a major point of review for new applicants, for renewal applications and indeed for any application if a PI is perceived to have too much funding. Productivity as reflected in peer reviewed published papers is not always under the direct control of the research team- the publication racket can induce significant unexpected delays. This pre-print policy allows the grant applicant to post pretty much anything that they want. It will potentially function as a hybrid of Preliminary Data and Publications. “Potentially” because there is no obligation for any reviewer to consider these documents.

I have decided to respond to this new initiative, for now, by submitting manuscripts to bioRχiv ( I have found the submission process to be relatively easy on the scale of the usual manuscript submission for publication or to the PMC repository. The first two I submitted were available online within 24 h of my upload.

The critical question for most of us will be to try to determine what our threshold should be for publicizing any pre-print or interim research product. I have come to the conclusion that a manuscript that we have already submitted for publication somewhere clearly fits the bill as a sufficiently complete work to put on a pre-print server. A manuscript that we plan to submit for peer review essentially concurrently is also very clearly sufficient and the only difference here, to my view, is whether we are really, really at a submittable-draft stage or maybe jumping the gun with the pre-print.

The following three manuscripts had already been reviewed by the time I put them up on bioRχiv. I would characterize two of the reviews as being concerned about interpretation of the data in a way that would require a LOT more data to satisfy. This appears to me to satisfy one potential goal of posting pre-prints. I.e., that people can interpret the quality and meaning of the data for themselves before the authors manage to satisfy all theoretical concerns, sidelines or unlikely possibilities that might be required for publication acceptance. The third one is awaiting one more figure of data for the resubmission. We thought we had a decent rebuttal without it, one that would possibly fly with the editor. But we are also generating new data that is relevant. This has been slower to emerge than I had hoped and we have noticed some recent publication activity in this area. Posting this manuscript as a pre-print is essentially putting down a priority marker at this time.

Javadi-Paydar, M., Nguyen, J.D., Grant, Y., Vandewater, S.A., Cole, M., and Taffe, M.A. Effects Of Δ9-THC And Cannabidiol Vapor Inhalation In Male And Female Rats.  bioRχiv, 2017, Posted April 18, 2017 doi:

Taffe, M.A. Wheel running increases hyperthermia and mortality rate following 3,4-methylenedioxymethamphetamine (MDMA) in rats. bioRχiv, 2017, Posted April 11, 2017 doi:

Aarde, S.M., Huang, P-K  and Taffe, M.A. High Ambient Temperature Facilitates The Acquisition Of 3,4-Methylenedioxymethamphetamine (MDMA) Self-Administration. bioRχiv, 2017, Posted April 4, 2017 doi:



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